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Research

We conduct transformational, community-centered research that improves healthcare equity and access—all while expanding the medical understanding of LGBTQ+ health and wellness.

Giving Our Community a Seat at the Table Since 1990

For more than 30 years, our Research Program has led studies that have: helped develop life-saving HIV medications; demonstrated the efficacy of PrEP and PEP to prevent HIV transmissions; develop innovative interventions to to reduce HIV and STI rates; and so much more. Our Program has always prioritized queer, trans, and BIPOC communities—bringing much-needed perspective to scientific research that, in turn, increases the equity of care for our people.

Our Point of Difference

It's About Community

We adhere to the fundamental principles of community-centered and community-engaged research. That means we build our research strategy around a foundational commitment to anti-racism, diversity, equity, and inclusion.

We Expand the Possibilities of Care

Through our methodological rigor and community-focused approach, we design research that has proven to lead to feasible, sustainable improvements in the health and wellbeing of our people.

We Bring You to the Center

Expanding the Center's holistic model of care, we prioritize research access for underserved, vulnerable, and understudied populations.

2022 Annual Stats:

1,000 People Currently Enrolled in Research Studies
30+ Years of Cutting-Edge HIV & STI Research
Top Performing MPOX Study in the United States
50+ Gold-Standard Clinical Studies

Get Involved: Current Studies

CAPABLE California Cannabis Study

Quantitative survey among clients attending Federally Qualified Health Centers in California to assess population estimates of prevalence, frequency, quantity, and reasons for use of medicinal cannabis.

Community-Based Assessment and Realignment for Long-Acting PrEP (CARE-LA)

The CARE-LA study focuses on increasing access to long-acting injectable PrEP among Black and Latinx MSM and Trans populations in Southern California. Study aims center on building a learning collaborative to support pharmacies and clinics in addressing the barriers and challenges to LAI PrEP delivery. The study also includes a community advisory board to support development of culturally relevant, equity-focused outreach and advertising campaigns.

Developing HPV Vaccination Profiles to Identify Targets for Public Health Messaging

Quantitative survey among men who have sex with men (MSM)—with and without HPV vaccinations—to understand sociodemographic and other characteristics that will inform better public health messaging.

Doxy PEP Implementation

Qualitative interviews and quantitative surveys to understand provider prescribing patterns and patient use with respect to CDC guidelines, and to increase uptake.

MACS/WIHS Combined Cohort Study (MWCCS)

Since 1984, the NIH has supported this longitudinal observational study of people living with or at risk for HIV. The Center has been a site for this study since 1995. This longitudinal study is a collaborative research effort to understand and reduce the impact of chronic health conditions (heart, lung, blood, and sleep disorders) that affect people living with HIV. A cohort of 120 men who have sex with men have been participating in the LA LGBT Center MWCCS site since 2003.

PEOPLE & PLACE: Impacts on Substance Use and HIV Outcomes in Los Angeles

Exploring how people living with HIV navigate the geography of Los Angeles County to receive substance use recovery services and HIV treatment and care. We will interrogate how public policies and practices influence movement of of PLWH across social and geographic spaces, specifically to understand how these patterns influence where they choose to receive care. We will adapt an evidence-based intervention, LINKLA, to understand how peer case managers can facilitate access to services and support participants in accessing substance use and HIV services within their neighborhoods of choice.

PrEP Well STAIR Study

The STAIR study will enroll transgender and gender diverse (TGD) individuals in Los Angeles County who are at high risk for HIV. The intervention integrates "PrEP Well," a PrEP navigation program, with "Trans STAIR," a culturally adapted trauma treatment addressing PTSD, depression, and substance use. The study aims to evaluate the effectiveness of Trans STAIR + PrEP Well in improving PrEP adherence and reducing mental health symptoms compared to PrEP Well alone.

Sexual Rights, Policy, and Pleasure in Los Angeles County Youth

Qualitative and quantitative data collection to understand 15–24-year olds’ experiences, perceptions, knowledge, attitudes around sexuality. This pilot project will generate preliminary data to inform further research and to guide development of policy and education around sexual health for this highly understudied, vulnerable population.

Tobacco Cessation Intervention for Trans and Nonbinary Adults: “QT” STUDY

Community-driven adaptation of an evidence-based smoking cessation intervention based at Trans Wellness Center. We use qualitative interviews to inform the adaptation of this 8-session intervention to ensure cultural relevance of tools, skills, exercises, etc.

Trans-Led Care Study (TLC)

Study to create a new gender-affirming, community-led wellness program for trans people who drink alcohol or use drugs, utilizing Acceptance and Commitment Therapy (ACT).

TRANS WEALTH STUDY: Guaranteed Income Pilot Study for TGI PLWH

To respond to disproportionate impact of socioeconomic disparities on TGI folx, guaranteed income is a social justice intervention to reduce systemic barriers and allow individuals to reallocate time and resources to focus on health and preventive health behaviors. 30 people will be randomized to receive guaranteed income over 6 months together with support from the Trans Employment and Empowerment Program (including financial literacy, financial planning, education and career guidance, etc.)
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